**Fatigue** is a state that negatively affects the driver, as it causes symptoms such as difficulty concentrating, blurred vision, slow movements, and increased irritability. These symptoms can make it more difficult for the driver to make decisions and react appropriately on the road.

On the other hand, **alcohol** also affects the driver's condition, and its impact can vary depending on factors such as weight, gender, the amount of alcohol consumed, and the time elapsed since its intake. Alcohol decreases reaction and concentration capacity, which increases the risk of accidents.

When a person is **fatigued**, these negative effects of alcohol are **aggravated**. Fatigue and alcohol together can intensify the difficulty in concentrating, increase reaction time, and worsen decision-making ability, which significantly increases the risk of having an accident. Therefore, it is crucial to avoid driving under the influence of alcohol, especially if fatigued.